Recent progress on the role and molecular mechanism of chicken ovalbumin upstream promoter-transcription factor II in cancer

Recent progress on the role and molecular mechanism of chicken ovalbumin upstream promoter-transcription factor II in cancer

Blog Article

Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) is an orphan receptor that regulates the expression of genes involved in development and homeostasis.COUP-TFII is also dysregulated in cancer, where it plays important roles in oncogenesis and malignant progression.Recent studies have also investigated altered microRNA-mediated regulation of COUP-TFII in cancer.Although many investigators have studied the deus gorras expression and clinical significance of COUP-TFII in several cancer types, there remain many controversies regarding its role here in these diseases.

In this review, we will describe the functions and underlying molecular mechanisms of COUP-TFII in several cancers, especially colorectal, gastric, breast, and prostate cancer; additionally, we will briefly summarize what is known about microRNA-mediated regulation of COUP-TFII.